Conceptional considerations for a German influenza pandemic preparedness plan
Identifieur interne : 001783 ( Main/Exploration ); précédent : 001782; suivant : 001784Conceptional considerations for a German influenza pandemic preparedness plan
Auteurs : R. Fock [Allemagne] ; H. Bergmann [Allemagne] ; H. Bussmann [Allemagne] ; G. Fell [Allemagne] ; E.-J. Finke [Allemagne] ; U. Koch [Allemagne] ; M. Niedrig [Allemagne] ; M. Peters [Allemagne] ; D. Scholz [Allemagne] ; A. Wirtz [Allemagne]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 2002-12-01.
English descriptors
Abstract
Abstract.: A pandemic appearance of influenza A virus must be expected at any time. The limitations of health preserving and life-saving resources, which will inevitably be reached in the event of a pandemic, will be accompanied by ethical and possibly social conflicts, which can be lessened or resolved only through precautionary planning, clearly specified competencies and transparent decisions within a social consensus. In case of a shortage of vaccines and virostatic agents, decisions will have to be made with regard to the segment of the population that absolutely must be vaccinated. It is currently estimated that a (monovalent) vaccine developed for a new pandemic strain would only suffice for the single vaccination of approximately half of the German population after a year; only 10–14 million vaccine dosages would be available to provide basic immunization and single boosters to personnel required to maintain basic medical care and essential infrastructure after half a year. In the event of local influenza outbreaks, antiviral chemotherapeutic agents could be used to close the gap until a vaccine can become effective. Even if suitable influenza vaccines and virostatic agents are not sufficiently available at the start of a pandemic, it is still possible to at least prevent an outbreak of two of the most feared secondary infections that accompany influenza: pneumococcal pneumonia or meningitis and illnesses resulting from Haemophilus influenzae. Agreement still needs to be reached with manufacturers for guaranteeing the necessary vaccine production or ensuring that they have a sufficient stock to meet the minimum demand for antiviral agents and agents for symptomatic treatment.
Url:
DOI: 10.1007/s00430-002-0145-y
Affiliations:
- Allemagne
- Bavière, Berlin, District de Cologne, District de Darmstadt, District de Haute-Bavière, Hambourg, Hesse (Land), Rhénanie-Palatinat, Rhénanie-du-Nord-Westphalie
- Berlin, Bonn, Francfort-sur-le-Main, Hambourg, Mayence, Munich
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The limitations of health preserving and life-saving resources, which will inevitably be reached in the event of a pandemic, will be accompanied by ethical and possibly social conflicts, which can be lessened or resolved only through precautionary planning, clearly specified competencies and transparent decisions within a social consensus. In case of a shortage of vaccines and virostatic agents, decisions will have to be made with regard to the segment of the population that absolutely must be vaccinated. It is currently estimated that a (monovalent) vaccine developed for a new pandemic strain would only suffice for the single vaccination of approximately half of the German population after a year; only 10–14 million vaccine dosages would be available to provide basic immunization and single boosters to personnel required to maintain basic medical care and essential infrastructure after half a year. In the event of local influenza outbreaks, antiviral chemotherapeutic agents could be used to close the gap until a vaccine can become effective. Even if suitable influenza vaccines and virostatic agents are not sufficiently available at the start of a pandemic, it is still possible to at least prevent an outbreak of two of the most feared secondary infections that accompany influenza: pneumococcal pneumonia or meningitis and illnesses resulting from Haemophilus influenzae. Agreement still needs to be reached with manufacturers for guaranteeing the necessary vaccine production or ensuring that they have a sufficient stock to meet the minimum demand for antiviral agents and agents for symptomatic treatment.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>Berlin</li><li>District de Cologne</li><li>District de Darmstadt</li><li>District de Haute-Bavière</li><li>Hambourg</li><li>Hesse (Land)</li><li>Rhénanie-Palatinat</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Berlin</li><li>Bonn</li><li>Francfort-sur-le-Main</li><li>Hambourg</li><li>Mayence</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Fock, R" sort="Fock, R" uniqKey="Fock R" first="R." last="Fock">R. Fock</name></region><name sortKey="Bergmann, H" sort="Bergmann, H" uniqKey="Bergmann H" first="H." last="Bergmann">H. Bergmann</name><name sortKey="Bussmann, H" sort="Bussmann, H" uniqKey="Bussmann H" first="H." last="Bussmann">H. Bussmann</name><name sortKey="Fell, G" sort="Fell, G" uniqKey="Fell G" first="G." last="Fell">G. Fell</name><name sortKey="Finke, E J" sort="Finke, E J" uniqKey="Finke E" first="E.-J." last="Finke">E.-J. Finke</name><name sortKey="Fock, R" sort="Fock, R" uniqKey="Fock R" first="R." last="Fock">R. Fock</name><name sortKey="Koch, U" sort="Koch, U" uniqKey="Koch U" first="U." last="Koch">U. Koch</name><name sortKey="Niedrig, M" sort="Niedrig, M" uniqKey="Niedrig M" first="M." last="Niedrig">M. Niedrig</name><name sortKey="Peters, M" sort="Peters, M" uniqKey="Peters M" first="M." last="Peters">M. Peters</name><name sortKey="Scholz, D" sort="Scholz, D" uniqKey="Scholz D" first="D." last="Scholz">D. Scholz</name><name sortKey="Wirtz, A" sort="Wirtz, A" uniqKey="Wirtz A" first="A." last="Wirtz">A. 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